Green and Efficient Construction of imidazo[2,1-b][1,3,4]thiadiazoles using Lanthanide Doped Magnesium Ferrite Nanoparticals through Multicomponenet GBB annulation
DOI:
https://doi.org/10.29070/k7tsdw85Keywords:
lanthanide doped magnesium ferrite, MgCe0.4Er0.6FeO4, nanopartical, Groebke–Blackburn–Bienaymé reaction, imidazo[2,1-b][1,3,4]thiadiazoleAbstract
lanthanide doped magnesium ferrite nanoparticles act as highly efficient heterogeneous catalysts in the Groebke–Blackburn–Bienaymé (GBB) Synthetic approach, promoting the annulation of 2-amino-1,3,4-thiadiazole with isocyanides and aldehydes to synthesize imidazo[2,1-b][1,3,4]thiadiazoles and bond-forming efficiency and procedural simplicity, enabling the rapid and economical construction of complex bioactive and structurally diverse molecular scaffolds.. Under the optimized conditions, 10 mol% MgCe0.4Er0.6FeO4 in dichloromethane at 50 °C afforded the model product in 94% isolated yield within 40 min. The catalyst could be separated readily and reused for six consecutive cycles (with isolated yields of 94, 94, 92, 92, 90 and 87%, respectively) thereby making the process economically viable, eco-compatible for large-scale and industrial implementation. The protocol also provided a series of imidazothiadiazole derivatives in good to excellent yields. UV–Visible, FT-IR, XRD and SEM measurements were used to characterize the prepared nanomaterial.
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